pragma.vision Technology observatory & strategic foresight

Verification register Bio, Health & Neuro

Readiness verdict

RFD4-Proteina

A dated reading of what is claimed, reported, and independently verified in the current evidence.

As of
2026-10-29
Revision
1
Method
v1.3.0

Current reading

Readiness band and full integer triple

AI-assisted assembly · derived results

Readiness band

Watch

Primary summary from verified readiness

Confidence
89% · fresh
Computed at
2026-10-29T16:46:17.66176+00:00
Claimed
55

Public ambition and stated capability

Reported
55

Observed practitioner reporting

Verified
51

Independently supported evidence

Gap
+4

Claimed leads verified

Evidence strength Critical

Decision

What the current evidence supports

Human editorial judgment · 2026-10-29

Proceed with caution

Why
Code, 0.4B-parameter weights and a hosted service are openly released under BSD-3-Clause, and the reported wet-lab results (158 of 188 TrkA binders under 1 micromolar, pooled across two campaigns) are strong. They are still developer-reported from a non-peer-reviewed preprint, with a Linux/CUDA-only runtime and screening oracles that measure confidence rather than activity. That supports evaluation in a research workflow with independent validation, not production reliance.
Next
Run the open model on one internal target alongside the incumbent method. Score the binder interface with an independent oracle, plan wet-lab confirmation, and re-check once the peer-reviewed paper and independent benchmarks appear.

Constraints

Blockers

No named blocker is present in the current public projection.

Evidence summary

Derived counts

AI-assisted assembly

Total
8
Tier 1
6
Tier 2
2
Tier 3
0
Supports
4
Contradicts
1
Context
3
Latest observed
2026-10-28

Counts and dates only. Raw signals, private excerpts, trust records, and internal corpus material are not published here.

Publication record

Revisions

Initial public reading

  1. 2026-10-29 Initial recorded band: watch.

Your opinion

Tell us anything.

What works, what doesn't, what's missing — especially about our watches, lenses, and the register itself. Anonymous is fine; leave an email if you'd like a reply.