Protenix

A dated reading of what is claimed, reported, and independently verified in the current evidence.

Current reading

Readiness band and full integer triple

AI-assisted assembly · derived results

Readiness band

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Primary summary from verified readiness

Evidence strength Strong

Decision

Agent-assisted assessment · independently reviewed · 2026-10-01

Consider Protenix-v2 for supervised research pilots if model access and licensing suit your workflow.

Why: Independent tests demonstrate useful structural modelling, but ligand geometry and binding-pose failures limit reliance on individual predictions.
Next: Benchmark the exact configuration on representative experimental structures, inspect ligand chemistry and ranking, and experimentally test consequential hypotheses.

Constraints

Protenix-v2 weights have proprietary access and redistribution restrictions.
Ligand topology, chirality and steric clashes require explicit validation.
Blind ion-channel ligand-pose prediction remains unreliable under the tested sampling budget.
Confidence ranking can miss the best sampled pose.
Large channel assemblies and ligand representations can cause execution failures.
Training-Free Guidance was not covered by the independent practitioner benchmark.

Evidence summary

AI-assisted assembly

Counts and dates only. Raw signals, private excerpts, trust records, and internal corpus material are not published here.

Publication record

Revision 4