Verification register Bio, Health & Neuro
Current reading
The readiness gap, in one scan
AI-assisted assembly · derived results
- Claimed
- 70
- Reported
- 70
- Verified
- 64
- Gap
- +6
Public ambition and stated capability
Observed practitioner reporting
Independently supported evidence
Claimed minus verified
Evidence strength Strong
Decision
What the current evidence supports
Human editorial judgment · 2026-06-28
Adopt with guardrails
- Why
- Nature-published (2025-07-30), openly available, with measured on-target parity (55.7% vs 48.3% median indel) and ~95% lower off-target editing (0.32% vs 6.1%) whose off-targets are a subset of SpCas9's with no new edits — strong for research adoption; the guardrails are licensing and the absence of in vivo therapeutic validation.
- Next
- Use the open GitHub/AddGene sequence for in vitro / research editing where higher specificity matters; benchmark against SpCas9 on your loci. For any commercial/therapeutic path, execute the Profluent license and run full biosafety evaluation first.
Constraints
Blockers
No named blocker is present in the current public projection.
Evidence summary
Derived counts
AI-assisted assembly
- Total
- 6
- Tier 1
- 0
- Tier 2
- 4
- Tier 3
- 2
- Supports
- 4
- Contradicts
- 1
- Context
- 1
- Latest observed
- 2026-01-01
Counts and dates only. Raw signals, private excerpts, trust records, and internal corpus material are not published here.
Publication record
Revisions
Initial public reading
This is the initial public reading. No earlier readiness change is recorded.