Verification register Bio, Health & Neuro
Current reading
Readiness band and full integer triple
AI-assisted assembly · derived results
Readiness band
Ready
Primary summary from verified readiness
- Confidence
- 79% · stale
- Computed at
- 2026-08-20T10:54:19.730593+00:00
- Claimed
- 70
- Reported
- 70
- Verified
- 64
- Gap
- +6
Public ambition and stated capability
Observed practitioner reporting
Independently supported evidence
Claimed leads verified
Evidence strength Strong
Decision
What the current evidence supports
Human editorial judgment · 2026-08-20
Adopt with guardrails
- Why
- Nature-published (2025-07-30), openly available, with measured on-target parity (55.7% vs 48.3% median indel) and ~95% lower off-target editing (0.32% vs 6.1%) whose off-targets are a subset of SpCas9's with no new edits — strong for research adoption; the guardrails are licensing and the absence of in vivo therapeutic validation.
- Next
- Use the open GitHub/AddGene sequence for in vitro / research editing where higher specificity matters; benchmark against SpCas9 on your loci. For any commercial/therapeutic path, execute the Profluent license and run full biosafety evaluation first.
Constraints
Blockers
No named blocker is present in the current public projection.
Evidence summary
Derived counts
AI-assisted assembly
- Total
- 11
- Tier 1
- 0
- Tier 2
- 8
- Tier 3
- 3
- Supports
- 8
- Contradicts
- 2
- Context
- 1
- Latest observed
- 2026-01-01
Counts and dates only. Raw signals, private excerpts, trust records, and internal corpus material are not published here.
Publication record
Revisions
Initial public reading
- 2026-07-19 Reading moved from ready to ready.