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Verification register Bio, Health & Neuro

Readiness verdict

ESMFold2 + ESM-C (Biohub World Model of Protein Biology)

A dated reading of what is claimed, reported, and independently verified in the current evidence.

As of
2026-09-22
Revision
2
Method
v1.3.0

Current reading

Readiness band and full integer triple

AI-assisted assembly · derived results

Readiness band

Ready

Primary summary from verified readiness

Confidence
72% · stale
Computed at
2026-09-22T23:27:14.984527+00:00
Claimed
80

Public ambition and stated capability

Reported
73

Observed practitioner reporting

Verified
64

Independently supported evidence

Gap
+16

Claimed leads verified

Evidence strength Critical

Decision

What the current evidence supports

Human editorial judgment · 2026-09-22

Adopt with guardrails

Why
MIT-licensed, openly available, strong measured results (de novo scFv at 4.3 nM PD-L1, antibody-antigen leadership where AlphaFold is weak) and very high activity make it a low-friction-to-try foundation, but preprint status and uneven modality reliability require guardrails.
Next
Pilot ESM-C embeddings + ESMFold2-Fast on an internal antibody/binder task behind validation gates; treat structure outputs as hypotheses pending wet-lab confirmation.

Constraints

Blockers

No named blocker is present in the current public projection.

Evidence summary

Derived counts

AI-assisted assembly

Total
6
Tier 1
2
Tier 2
4
Tier 3
0
Supports
3
Contradicts
2
Context
1
Latest observed
2026-06-23

Counts and dates only. Raw signals, private excerpts, trust records, and internal corpus material are not published here.

Publication record

Revisions

Revision 2

  1. 2026-07-19 Reading moved from ready to ready.
  2. 2026-09-22 Reading moved from ready to ready.

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