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Verification register Bio, Health & Neuro

Readiness verdict

ESMFold2 + ESM-C (Biohub World Model of Protein Biology)

A dated reading of what is claimed, reported, and independently verified in the current evidence.

As of
2026-06-28
Revision
1
Method
v1.0.0

Current reading

The readiness gap, in one scan

AI-assisted assembly · derived results

Claimed
80

Public ambition and stated capability

Reported
73

Observed practitioner reporting

Verified
64

Independently supported evidence

Gap
+16

Claimed minus verified

Evidence strength Critical

Decision

What the current evidence supports

Human editorial judgment · 2026-06-28

Adopt with guardrails

Why
MIT-licensed, openly available, strong measured results (de novo scFv at 4.3 nM PD-L1, antibody-antigen leadership where AlphaFold is weak) and very high activity make it a low-friction-to-try foundation, but preprint status and uneven modality reliability require guardrails.
Next
Pilot ESM-C embeddings + ESMFold2-Fast on an internal antibody/binder task behind validation gates; treat structure outputs as hypotheses pending wet-lab confirmation.

Constraints

Blockers

No named blocker is present in the current public projection.

Evidence summary

Derived counts

AI-assisted assembly

Total
6
Tier 1
0
Tier 2
4
Tier 3
2
Supports
3
Contradicts
2
Context
1
Latest observed
2026-06-23

Counts and dates only. Raw signals, private excerpts, trust records, and internal corpus material are not published here.

Publication record

Revisions

Initial public reading

This is the initial public reading. No earlier readiness change is recorded.

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