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Verification register Bio, Health & Neuro

Readiness verdict

Boltz-2

A dated reading of what is claimed, reported, and independently verified in the current evidence.

As of
2026-06-28
Revision
1
Method
v1.0.0

Current reading

The readiness gap, in one scan

AI-assisted assembly · derived results

Claimed
75

Public ambition and stated capability

Reported
66

Observed practitioner reporting

Verified
57

Independently supported evidence

Gap
+18

Claimed minus verified

Evidence strength Strong

Decision

What the current evidence supports

Human editorial judgment · 2026-06-28

Adopt with guardrails

Why
Open MIT-licensed, fast, and strong on held-out FEP+/CASP16, but a large body of independent benchmarks documents narrow dynamic range, memorization, and instability — usable for triage, not as a physics replacement.
Next
Deploy for fast triage/enrichment in early virtual screening with target-specific calibration and a physics-based (FEP) confirmation gate; avoid molecular glues and flexible-pocket targets, and validate against in-house actives before trusting rankings.

Constraints

Blockers

No named blocker is present in the current public projection.

Evidence summary

Derived counts

AI-assisted assembly

Total
7
Tier 1
0
Tier 2
4
Tier 3
3
Supports
3
Contradicts
3
Context
1
Latest observed
2026-02-01

Counts and dates only. Raw signals, private excerpts, trust records, and internal corpus material are not published here.

Publication record

Revisions

Initial public reading

This is the initial public reading. No earlier readiness change is recorded.

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