Living definition
What is ESM3?
Protein Design & Computational Biology Bio, Health & Neuro
- As of
- 2026-10-01
- Revision
- 2026-10-06.1
- Method
- v1.4.0
Definition
The term, in context
AI-assisted draft · approved dataset
ESM3 is a generative protein language model that reasons jointly over sequence, structure, and function, letting a protein be specified by partial constraints in any of those channels and completed in the others.
Live readiness status
Status as of the current dateline
AI-assisted assembly · derived results
As of 2026-10-01, verified readiness is 35 (claimed 55, reported 35, gap 20) — Growing evidence strength; current signals suggest Use ESM3 for constrained protein-design research with experimental follow-up.
The readiness fact belongs to the canonical Readiness Verdict for ESM3.
Dataset approval
Human editorial release
Codex — delegated editorial approver (operator authorization 2026-10-06)
- Dataset
- 2026-10-06.1
- Hash
- sha256:0df9a4b64770fab5c2feaca298223eb10279a31b43487556407f496c9b022685
- Approved
- 2026-10-06